Endocrine Abstracts

Background: Radioactive iodine (RAI) is a safe and effective treatment for management of hyperthyroidism caused by Graves’ disease and multinodular goitres. However, patient engagement with this therapy is limited by concerns regarding significant weight gain following treatment. We therefore aimed to audit weight changes in individuals receiving RAI within our service and identify factors that may influence this outcome.Met...

Adipose tissue inflammation may be an important mechanism in the development of systemic insulin resistance, such that modulation of this system may be a therapeutic target for type 2 diabetes and obesity-related disorders. AMPK has anti-inflammatory properties, yet the anti-inflammatory actions of AMPK in adipocytes remain poorly characterised. We questioned whether AMPK activation influences pro-inflammatory responses in cultured adipocytes in basal and stimulated conditions...

The increasing global prevalence of obesity requires urgent intervention to limit the anticipated surge of associated cardiometabolic morbidity and mortality. The energy sensor AMP-activated protein kinase (AMPK) is one proposed target for treating metabolic disorders and is downregulated in adipose tissue of obese insulin resistant individuals. Given the strong relationship between metabolic syndrome and overactivity of the renin-angiotensin-aldosterone system (RAAS) we inves...